High Expression of PR-A and Low Expression of PR-B is Correlated with Inflammation in Endometrioma Cases

BACKGROUND: Progestin therapy has been commonly used in endometriosis. The regulation of progesterone receptors B (PR-B) greatly affects the success rate cases presence tumor necrosis factor (TNF)-a endometriosis triggers PR-B hypermethylation, decreasing expression and PR-B/A ratio that induce resistance. It may also occur endometrioma. Studies regarding distribution PR-A with TNF-a endometrioma tissue samples not elucidated well. Therefore, this study was conducted to measure compare expression, assess effect on benign cysts.METHODS: A cross-sectional by collecting paraffin blocks endometriomas cysts as controls, from patients undergoing surgery at Dr. Sardjito Hospital, Yogyakarta. Immunohistochemistry performed expressions PR-A, PR-B, ratio, compared differences between cysts.RESULTS: Twenty-three 22 cyst were collected. mean found be lower than cysts, higher cysts. However, there no significant correlations severity.CONCLUSION: In cases, higher, while lower. relationship TNF-a.KEYWORDS: receptor, factor-alpha, endometriosis, endometrioma, cyst, ovarian